REACTIVE CHANGES OF THE VISCERAL MESOTHELIUM IN THE EXPERIMENTAL PERITONITIS

The mortality from peritonitis is still high, so the question of pathogenesis this disease remains relevant. Of considerable interest are reactive and compensatory-adaptive changes in liver tissues during development peritonitis, since both general state body postoperative period depend on liver. purpose study was mesothelial cells serous membrane conditions acute experimental laboratory mice. White mice were used amount 35 individuals sexes at age 3 months weighing 25–30 grams. Animals under ether anesthesia made laparotomy abdominal cavity contaminated with a mixture containing autopunctate terminal part small intestine blood rate 10 ml per 1 kg weight. Peritonitis reproduced by creating focus necrotic damage ventral wall cavity. control group animals injected saline. material Morphometric electronic microscopy research methods, method film preparations mesothelium subsequent impregnation silver used. As result study, it found that accompanied structural tissues, expressed differently different periods inflammation. noted systemic involve hepatocytes, hepatic beams cholangiocytes interlobular excretory bile ducts, sheath, connective tissue layers portal tracts, as well cellular elements sinusoids perisinusoidal space. With exudation capsule increases becomes maximum 7th day experiment, undergo dystrophic changes. attenuation 2–4 weeks processes weaken its normalizes. Thus, conducted microscopic morphometric studies prove regular